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Kinetically Favored Platination of Adenine in the G-Rich Human Telomeric Repeat
[Image: see text] The interactions of PT-ACRAMTU, a cytotoxic platinum–acridine conjugate, with the human telomeric G-quadruplex have been studied using in-line high-performance liquid chromatography–mass spectrometry and footprinting assays. The conjugate reacts significantly faster with quadruplex...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2536596/ https://ncbi.nlm.nih.gov/pubmed/18047349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja077390a |
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