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Dependence of Effective Molarity on Linker Length for an Intramolecular Protein-Ligand System

This paper reports dissociation constants and “effective molarities” (M(eff)) for the intramolecular binding of a ligand covalently attached to the surface of a protein by oligo(ethylene glycol) (EG(n)) linkers of different lengths (n = 0, 2, 5, 10, and 20), and compares these experimental values wi...

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Main Authors: Krishnamurthy, Vijay M., Semetey, Vincent, Bracher, Paul J., Shen, Nan, Whitesides, George M.
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535942/
https://ncbi.nlm.nih.gov/pubmed/17263415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja066780e
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