Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification

SUMMARY: Custom-made zinc-finger nucleases (ZFNs) can induce targeted genome modifications with high efficiency in cell types including Drosophila, C. elegans, plants, and humans. A bottleneck in the application of ZFN technology has been the generation of highly specific engineered zinc-finger arra...

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Hauptverfasser: Maeder, Morgan L., Thibodeau-Beganny, Stacey, Osiak, Anna, Wright, David A., Anthony, Reshma M., Eichtinger, Magdalena, Jiang, Tao, Foley, Jonathan E., Winfrey, Ronnie J., Townsend, Jeffrey A., Unger-Wallace, Erica, Sander, Jeffry D., Müller-Lerch, Felix, Fu, Fengli, Pearlberg, Joseph, Göbel, Carl, Dassie, Justin P., Pruett-Miller, Shondra M., Porteus, Matthew H., Sgroi, Dennis C., Iafrate, A. John, Dobbs, Drena, McCray, Paul B., Cathomen, Toni, Voytas, Daniel F., Joung, J. Keith
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535758/
https://ncbi.nlm.nih.gov/pubmed/18657511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.06.016
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