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Tailoring Relaxation Dispersion Experiments for Fast-Associating Protein Complexes

NMR relaxation dispersion spectroscopy is a powerful technique to elucidate the mechanism of protein-protein binding reactions. However, it is difficult to optimize the concentration ratios that give relaxation dispersions of appropriate amplitude to determine accurate kinetic and thermodynamic para...

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Detalhes bibliográficos
Main Authors: Sugase, Kenji, Lansing, Jonathan C., Dyson, H. Jane, Wright, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533806/
https://ncbi.nlm.nih.gov/pubmed/17935336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0762238
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