First Assessment in Humans of the Safety, Tolerability, Pharmacokinetics, and Ex Vivo Pharmacodynamic Antimalarial Activity of the New Artemisinin Derivative Artemisone

In preclinical studies, artemisone (BAY 44-9585), a new artemisinin derivative, was shown to possess enhanced efficacy over artesunate, and it does not possess the neurotoxicity characteristic of the current artemisinins. In a phase I program with double-blind, randomized, placebo-controlled, single...

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Detalhes bibliográficos
Main Authors: Nagelschmitz, Johannes, Voith, Barbara, Wensing, Georg, Roemer, Axel, Fugmann, Burkhard, Haynes, Richard K., Kotecka, Barbara M., Rieckmann, Karl H., Edstein, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533467/
https://ncbi.nlm.nih.gov/pubmed/18559649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01585-07
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