Identification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput Screen

West Nile virus and dengue virus are mosquito-borne flaviviruses that cause a large number of human infections each year. No vaccines or chemotherapeutics are currently available. These viruses encode a serine protease that is essential for polyprotein processing, a required step in the viral replic...

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Main Authors: Mueller, Niklaus H., Pattabiraman, Nagarajan, Ansarah-Sobrinho, Camilo, Viswanathan, Prasanth, Pierson, Theodore C., Padmanabhan, R.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2008
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533463/
https://ncbi.nlm.nih.gov/pubmed/18606844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01508-07
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