Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats

There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. Th...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Abe, Fumie, Ueyama, Jun, Kawasumi, Noriyo, Nadai, Masayuki, Hayashi, Tamon, Kato, Miki, Ohnishi, Masafumi, Saito, Hiroko, Takeyama, Naoshi, Hasegawa, Takaaki
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2008
נושאים:
Experimental Therapeutics
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533450/
https://ncbi.nlm.nih.gov/pubmed/18591270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00396-08
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