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Site-specific Delivery of Oligonucleotides to Hepatocytes after Systemic Administration
We previously complexed ODN with galactosylated poly (L-lysine) (Gal-PLL) to enhance its site specific delivery to hepatocytes. To avoid the use of polycations, in this study we conjugated galactosylated poly (ethylene glycol) (Gal-PEG (MW of PEG: 3486±500Da)) to ODN via an acid labile ester linkage...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533433/ https://ncbi.nlm.nih.gov/pubmed/17850109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc070126m |
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