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d- and l-2′,3′-Didehydro-2′,3′-Dideoxy-3′-Fluoro-Carbocyclic Nucleosides: Synthesis, Anti-HIV Activity and Mechanism of Resistance

Introducing 2′-fluoro substitution on the 2′,3′-double bond in carbocyclic nucleosides has provided biologically interesting compounds with potent anti-HIV activity. As an extension of our previous works in the discovery of anti-HIV agents, d- and l-2′,3′-unsaturated 3′-fluoro carbocyclic nucleoside...

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Bibliografske podrobnosti
Main Authors: Wang, Jianing, Jin, Yunho, Rapp, Kimberly L., Schinazi, Raymond F., Chu, Chung K.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533426/
https://ncbi.nlm.nih.gov/pubmed/17373782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061304k
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