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Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation
Cortical GABAergic dysfunction, a hallmark of both schizophrenia (SZ) and bipolar (BP) disorder pathophysiologies may relate to the hypermethylation of GABAergic gene promoters (i.e., reelin and GAD67). Benefits elicited by a combination of atypical antipsychotics with valproate (VPA) (a histone dea...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533238/ https://ncbi.nlm.nih.gov/pubmed/18757738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805493105 |
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