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Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen.

Proteolytic fragments of simian virus 40 tumor (T) antigen and T antigen that was dephosphorylated with alkaline phosphatase bound between 1.5 to 2 times more origin-containing simian virus 40 DNA than did intact T antigen in DNA saturation experiments. Kinetic experiments showed that these treatmen...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Simmons, D T, Chou, W, Rodgers, K
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 1986
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253314/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3023678/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.60.3.888-894.1986
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