Thyroid Hormone Receptor α1 Follows a Cooperative CRM1/Calreticulin-mediated Nuclear Export Pathway

The thyroid hormone receptor α1 (TRα) exhibits a dual role as an activator or repressor of its target genes in response to thyroid hormone (T(3)). Previously, we have shown that TRα, formerly thought to reside solely in the nucleus bound to DNA, actually shuttles rapidly between the nucleus and cyto...

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Autori principali: Grespin, Matthew E., Bonamy, Ghislain M. C., Roggero, Vincent R., Cameron, Nicole G., Adam, Lindsay E., Atchison, Andrew P., Fratto, Victoria M., Allison, Lizabeth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533095/
https://ncbi.nlm.nih.gov/pubmed/18641393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710482200
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