Ubiquitin-Proteasome-mediated Degradation of Keratin Intermediate Filaments in Mechanically Stimulated A549 Cells

We previously reported that shear stress induces phosphorylation and disassembly of keratin intermediate filaments (IFs). Shear stress also induces a time- and strain-dependent degradation of keratin IFs, and the current study examines the mechanisms involved in degradation of keratin proteins in hu...

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Detalhes bibliográficos
Main Authors: Jaitovich, Ariel, Mehta, Semil, Na, Ni, Ciechanover, Aaron, Goldman, Robert D., Ridge, Karen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533078/
https://ncbi.nlm.nih.gov/pubmed/18617517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801635200
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