Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression

Viral infection activates Toll-like receptor and RIG-I (retinoic acid-inducible gene I) signaling pathways, leading to phosphorylation of IRF3 (interferon regulatory factor 3) and IRF7 and stimulation of type I interferon (IFN) transcription, a process important for innate immunity. We show that upo...

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Autores principales: Kubota, Toru, Matsuoka, Mayumi, Chang, Tsung-Hsien, Tailor, Prafullakumar, Sasaki, Tsuguo, Tashiro, Masato, Kato, Atsushi, Ozato, Keiko
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533075/
https://ncbi.nlm.nih.gov/pubmed/18635538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804479200
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