Structure—Activity Relationships in the Binding of Chemically Derivatized CD4 to gp120 from Human Immunodeficiency Virus

The first step in HIV infection is the binding of the envelope glycoprotein gp120 to the host cell receptor CD4. An interfacial “Phe43 cavity” in gp120, adjacent to residue Phe43 of gp120-bound CD4, has been suggested as a potential target for therapeutic intervention. We designed a CD4 mutant (D1D2...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Xie, Hui, Ng, Danny, Savinov, Sergey N., Dey, Barna, Kwong, Peter D., Wyatt, Richard, Smith, Amos B., Hendrickson, Wayne A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2007
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532594/
https://ncbi.nlm.nih.gov/pubmed/17803292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070564e
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