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A Catalytic Domain Exosite (Cys(527)-Cys(542)) in Factor XIa Mediates Binding to a Site on Activated Platelets

The zymogen, factor XI, and the enzyme, factor XIa, interact specifically with functional receptors on the surface of activated platelets. The present studies were initiated to identify the molecular subdomain within factor XIa that binds to activated platelets. Both factor XIa (K(i) ~1.4 nM) and a...

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Detalhes bibliográficos
Main Authors: Miller, Tara N., Baird, T. Regan, Walsh, Peter N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532527/
https://ncbi.nlm.nih.gov/pubmed/18020374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701310x
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