De novo Discovery of Serotonin N-acetyltransferase Inhibitors

Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) is a member of the GCN5 N-acetyltransferase (GNAT) superfamily and catalyzes the penultimate step in the biosynthesis of melatonin; a large daily rhythm in AANAT activity drives the daily rhythm in circulating melatonin. We ha...

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Main Authors: Szewczuk, Lawrence M., Saldanha, S. Adrian, Ganguly, Surajit, Bowers, Erin M., Javoroncov, Margarita, Karanam, Balasubramanyam, Culhane, Jeffrey C., Holbert, Marc A., Klein, David C., Abagyan, Ruben, Cole, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531295/
https://ncbi.nlm.nih.gov/pubmed/17924613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0706463
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