Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin

Endothelial cells in growing tumors express activated Akt, which when modeled by transgenic endothelial expression of myrAkt1 was sufficient to recapitulate the abnormal structural and functional features of tumor blood vessels in nontumor tissues. Sustained endothelial Akt activation caused increas...

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Détails bibliographiques
Auteurs principaux: Phung, Thuy L., Ziv, Keren, Dabydeen, Donnette, Eyiah-Mensah, Godfred, Riveros, Marcela, Perruzzi, Carole, Sun, Jingfang, Monahan-Earley, Rita A., Shiojima, Ichiro, Nagy, Janice A., Lin, Michelle I., Walsh, Kenneth, Dvorak, Ann M., Briscoe, David M., Neeman, Michal, Sessa, William C., Dvorak, Harold F., Benjamin, Laura E.
Format: Artigo
Langue:Inglês
Publié: 2006
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2531257/
https://ncbi.nlm.nih.gov/pubmed/16904613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.07.003
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