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Derivatization with Girard Reagent T Combined with LC-MS/MS for the Sensitive Detection of 5-Formyl-2′-deoxyuridine in Cellular DNA
Nucleoside 5-formyl-2′-deoxyuridine (FodU) is a major thymidine lesion generated by reactive oxygen species. In-vitro and in-vivo replication studies revealed that FodU can be mutagenic. A reliable and sensitive quantification method is, therefore, important for assessing the biological implications...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2531228/ https://ncbi.nlm.nih.gov/pubmed/17194156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac061465w |
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