Epidermal Growth Factor Signaling and Mitogenesis in Plcg1 Null Mouse Embryonic Fibroblasts

Gene targeting techniques and early mouse embryos have been used to produce immortalized fibroblasts genetically deficient in phospholipase C (PLC)-γ1, a ubiquitous tyrosine kinase substrate. Plcg1(−/−) embryos die at embryonic day 9; however, cells derived from these embryos proliferate as well as...

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Bibliographic Details

Published in:	Mol Biol Cell
Main Authors:	Ji, Qun-sheng, Ermini, Sandra, Baulida, Josep, Sun, Feng-lei, Carpenter, Graham
Format:	Artigo
Language:	Inglês
Published:	American Society for Cell Biology 1998
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25303/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9529375/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.9.4.749
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