Epidermal Growth Factor Signaling and Mitogenesis in Plcg1 Null Mouse Embryonic Fibroblasts

Gene targeting techniques and early mouse embryos have been used to produce immortalized fibroblasts genetically deficient in phospholipase C (PLC)-γ1, a ubiquitous tyrosine kinase substrate. Plcg1(−/−) embryos die at embryonic day 9; however, cells derived from these embryos proliferate as well as...

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Main Authors: Ji, Qun-sheng, Ermini, Sandra, Baulida, Josep, Sun, Feng-lei, Carpenter, Graham
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 1998
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC25303/
https://ncbi.nlm.nih.gov/pubmed/9529375
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