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PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1
We have recently identified a new form of post-translational regulation of BACE1 (β-site amyloid precursor protein (APP)-cleaving enzyme 1), a membrane protein that acts as the rate-limiting enzyme in the generation of the Alzheimer disease amyloid β-peptide (Aβ). Specifically, BACE1 is transiently...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2529349/ https://ncbi.nlm.nih.gov/pubmed/18660751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.132 |
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