MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis

Microcephalin (MCPH1) has a crucial role in the DNA damage response by promoting the expression of Checkpoint kinase 1 (CHK1) and Breast cancer susceptibility gene 1 (BRCA1); however, the mechanism of this regulation remains unclear. Here, we show that MCPH1 regulates CHK1 and BRCA1 through the inte...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Yang, Shan-Zhong, Lin, Fang-Tsyr, Lin, Weei-Chin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2008
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529348/
https://ncbi.nlm.nih.gov/pubmed/18660752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.128
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