Genetic analysis of the attenuation phenotype of poliovirus type 1.

Seven different recombinant viruses from the virulent Mahoney and the attenuated Sabin parental strains of type 1 poliovirus were constructed in vitro by using infectious cDNA clones. Monkey neurovirulence tests (lesion score, spread value, and incidence of paralysis) using these recombinant viruses...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Omata, T, Kohara, M, Kuge, S, Komatsu, T, Abe, S, Semler, B L, Kameda, A, Itoh, H, Arita, M, Wimmer, E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1986
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC252919/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3009852/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.58.2.348-358.1986
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