Genetic analysis of the attenuation phenotype of poliovirus type 1.

Seven different recombinant viruses from the virulent Mahoney and the attenuated Sabin parental strains of type 1 poliovirus were constructed in vitro by using infectious cDNA clones. Monkey neurovirulence tests (lesion score, spread value, and incidence of paralysis) using these recombinant viruses...

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Bibliographic Details
Main Authors: Omata, T, Kohara, M, Kuge, S, Komatsu, T, Abe, S, Semler, B L, Kameda, A, Itoh, H, Arita, M, Wimmer, E
Format: Artigo
Language:Inglês
Published: 1986
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC252919/
https://ncbi.nlm.nih.gov/pubmed/3009852
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