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Identification of an INSM1 Binding Site in the Insulin Promoter: Negative Regulation of the Insulin Gene Transcription
In this study, an INSM1-binding site in the proximal promoter sequence of the insulin gene was identified. Co-transfection of INSM1 with rat insulin I/II promoter-driven reporter genes exhibited a 40-50% inhibitory effect on reporter activity. Mutational experiments were performed by introducing a s...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2529182/ https://ncbi.nlm.nih.gov/pubmed/18417529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-08-0001 |
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