Protection of Retinal Cells from Ischemia by a Novel Gap Junction Inhibitor

Retinal cells which become ischemic will pass apoptotic signal to adjacent cells, resulting in the spread of damage. This occurs through open gap junctions. A class of novel drugs, based on primaquine (PQ), was tested for binding to connexin 43 using simulated docking studies. A novel drug has been...

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Detalhes bibliográficos
Main Authors: Das, Satyabrata, Lin, Dingbo, Jena, Snehalata, Shi, Aibin, Battina, Srinivas, Hua, Duy H., Allbaugh, Rachel, Takemoto, Dolores J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529171/
https://ncbi.nlm.nih.gov/pubmed/18590704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.06.069
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