Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase

The replication terminator protein Tus of Escherichia coli promotes polar fork arrest at sequence-specific replication termini (Ter) by antagonizing DNA unwinding by the replicative helicase DnaB. Here, we report that Tus is also a polar antitranslocase. We have used this activity as a tool to uncou...

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Main Authors: Bastia, Deepak, Zzaman, Shamsu, Krings, Gregor, Saxena, Mukesh, Peng, Xiaohua, Greenberg, Marc M.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529109/
https://ncbi.nlm.nih.gov/pubmed/18708526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805898105
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