Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones

The epothilones represent a promising class of natural product-based antitumor drug candidates. Although these compounds operate through a microtubule stabilization mechanism similar to that of taxol, the epothilones offer a major potential therapeutic advantage in that they retain their activity ag...

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Main Authors: Chou, Ting-Chao, Zhang, Xiuguo, Zhong, Zi-Yang, Li, Yong, Feng, Li, Eng, Sara, Myles, David R., Johnson, Robert, Wu, Nian, Yin, Ye Ingrid, Wilson, Rebecca M., Danishefsky, Samuel J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Physical Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529025/
https://ncbi.nlm.nih.gov/pubmed/18755900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804773105
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