The Role of Kalirin9 in p75/Nogo Receptor-mediated RhoA Activation in Cerebellar Granule Neurons

p75 and the Nogo receptor form a signaling unit for myelin inhibitory molecules, with p75 being responsible for RhoA activation. Because p75 lacks the GDP/GTP exchange factor domain, it has remained unclear how p75 activates RhoA. Here, we report that Kalirin9, a dual RhoGEF, binds p75 directly and...

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Detaylı Bibliyografya
Asıl Yazarlar: Harrington, Anthony W., Li, Qi Ming, Tep, Chhavy, Park, Jong Bae, He, Zhigang, Yoon, Sung Ok
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2008
Konular:
Mechanisms of Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529002/
https://ncbi.nlm.nih.gov/pubmed/18625710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802188200
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