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The Werner Syndrome Protein Binds Replication Fork and Holliday Junction DNAs as an Oligomer
Werner syndrome is an inherited disease displaying a premature aging phenotype. The gene mutated in Werner syndrome encodes both a 3′ → 5′ DNA helicase and a 3′ → 5′ DNA exonuclease. Both WRN helicase and exonuclease preferentially utilize DNA substrates containing alternate secondary structures. By...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2528990/ https://ncbi.nlm.nih.gov/pubmed/18596042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803370200 |
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