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Novel Benzodiazepine Photoaffinity Probe Stereoselectively Labels a Site Deep Within the Membrane-spanning Domain of the Cholecystokinin Receptor

An understanding of the molecular basis of drug action provides opportunities for refinement of drug properties and for development of more potent and selective molecules that act at the same biological target. In this work, we have identified the active enantiomers in racemic mixtures of structural...

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Detalhes bibliográficos
Main Authors: Hadac, Elizabeth M., Dawson, Eric S., Darrow, James W., Sugg, Elizabeth E., Lybrand, Terry P., Miller, Laurence J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528300/
https://ncbi.nlm.nih.gov/pubmed/16451051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm049072h
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