Benzodiazepine receptor protein identified and visualized in brain tissue by a photoaffinity label.

Flunitrazepam, a potent benzodiazepine, reversibly binds to the benzodiazepine receptor with high affinity. When irradiated with UV light, flunitrazepam was irreversibly linked to brain tissue. Incorporation of [3H]flunitrazepam was inhibited by other benzodiazepines with a potency corresponding to...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Möhler, H, Battersby, M K, Richards, J G
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348558/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6103538/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.3.1666
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