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Peptide Prodrugs: Improved Oral Absorption of Lopinavir, a HIV Protease Inhibitor
Lopinavir (LVR) is extensively metabolized by CYP3A4 and is prevented from entering the cells by membrane efflux pumps such as P-gp and MRP2. In an approach to evade the first-pass metabolism and efflux of LVR, peptide prodrugs of LVR [valine-valine-lopinavir (VVL) and glycine-valine-lopinavir (GVL)...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2528298/ https://ncbi.nlm.nih.gov/pubmed/18455890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2008.03.031 |
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