Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

HIV-1 reverse transcriptase (RT) is a primary target for anti-AIDS drugs. Structures of HIV-1 RT, usually determined at ∼2.5–3.0 Å resolution, are important for understanding enzyme function and mechanisms of drug resistance in addition to being helpful in the design of RT inhibitors. Despite hundre...

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Bibliographische Detailangaben
Hauptverfasser: Bauman, Joseph D., Das, Kalyan, Ho, William C., Baweja, Mukta, Himmel, Daniel M., Clark, Arthur D., Oren, Deena A., Boyer, Paul L., Hughes, Stephen H., Shatkin, Aaron J., Arnold, Eddy
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528191/
https://ncbi.nlm.nih.gov/pubmed/18676450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn464
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