Molecular pathways involved in the synergistic interaction of the PKCβ inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells

Conventional regimens have limited impact against non-small cell lung cancer (NSCLC). Current research is focusing on multiple pathways as potential targets, and this study investigated molecular mechanisms underlying the combination of the PKCβ inhibitor enzastaurin with the multitargeted antifolat...

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Detalhes bibliográficos
Main Authors: Tekle, C, Giovannetti, E, Sigmond, J, Graff, J R, Smid, K, Peters, G J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528136/
https://ncbi.nlm.nih.gov/pubmed/18728666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604566
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