The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats

Enzastaurin is a Protein Kinase C-β selective inhibitor that was developed to treat cancers. Protein Kinase C-β is an important enzyme for a variety of neuronal functions; in particular, previous rodent studies have reported deficits in spatial and fear-conditioned learning and memory with lower lev...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Willeman, Mari N., Mennenga, Sarah E., Siniard, Ashley L., Corneveaux, Jason J., De Both, Matt, Hewitt, Lauren T., Tsang, Candy W. S., Caselli, Jason, Braden, B. Blair, Bimonte-Nelson, Heather A., Huentelman, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988320/
https://ncbi.nlm.nih.gov/pubmed/29870545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198256
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