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Molecular mechanism underlying the pharmacological interactions of the protein kinase C-β inhibitor enzastaurin and erlotinib in non-small cell lung cancer cells

Erlotinib is commonly used as a second line treatment in non-small cell lung cancer patients with sensitizing EGFR mutations. In EGFR-wild type patients, however the results are limited. Therefore we evaluated whether the combination of the Protein kinase C-β inhibitor enzastaurin with erlotinib cou...

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Dettagli Bibliografici
Pubblicato in:Am J Cancer Res
Autori principali: Steen, Nele Van Der, Potze, Lisette, Giovannetti, Elisa, Cavazzoni, Andrea, Ruijtenbeek, Rob, Rolfo, Christian, Pauwels, Patrick, Peters, Godefridus J
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411790/
https://ncbi.nlm.nih.gov/pubmed/28469955
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