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Energy-dependent fitness: A quantitative model for the evolution of yeast transcription factor binding sites

We present a genomewide cross-species analysis of regulation for broad-acting transcription factors in yeast. Our model for binding site evolution is founded on biophysics: the binding energy between transcription factor and site is a quantitative phenotype of regulatory function, and selection is g...

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Detalhes bibliográficos
Main Authors: Mustonen, Ville, Kinney, Justin, Callan, Curtis G., Lässig, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527919/
https://ncbi.nlm.nih.gov/pubmed/18723669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805909105
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