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Energy-dependent fitness: A quantitative model for the evolution of yeast transcription factor binding sites
We present a genomewide cross-species analysis of regulation for broad-acting transcription factors in yeast. Our model for binding site evolution is founded on biophysics: the binding energy between transcription factor and site is a quantitative phenotype of regulatory function, and selection is g...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527919/ https://ncbi.nlm.nih.gov/pubmed/18723669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805909105 |
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