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Nanomechanical Properties of Human Prion Protein Amyloid as Probed by Force Spectroscopy

Amyloids are associated with a number of protein misfolding disorders, including prion diseases. In this study, we used single-molecule force spectroscopy to characterize the nanomechanical properties and molecular structure of amyloid fibrils formed by human prion protein PrP90-231. Force-extension...

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Detalhes bibliográficos
Main Authors: Ganchev, Dragomir N., Cobb, Nathan J., Surewicz, Krystyna, Surewicz, Witold K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527243/
https://ncbi.nlm.nih.gov/pubmed/18539633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.133108
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