The Cleavage of Neutrophil Leukosialin (CD43) by Cathepsin G Releases Its Extracellular Domain and Triggers Its Intramembrane Proteolysis by Presenilin/γ-Secretase

The highly negatively charged membrane sialoglycoprotein leukosialin, CD43, is shed during neutrophil activation. This is generally thought to enhance cell adhesion. We here describe two novel consequences of this shedding, during neutrophil activation by phorbol esters or by chemoattractants after...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mambole, Agnès, Baruch, Dominique, Nusbaum, Patrick, Bigot, Sylvain, Suzuki, Misa, Lesavre, Philippe, Fukuda, Minoru, Halbwachs-Mecarelli, Lise
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2008
Pynciau:
Molecular Basis of Cell and Developmental Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527098/
https://ncbi.nlm.nih.gov/pubmed/18586676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710286200
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