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Studies on a Total Synthesis of the Microbial Immunosuppresive Agent FR901483
A strategy is outlined for construction of the fungal immunosuppressant FR901483 (1). It was possible to convert 1,4-cyclohexanedione monoethylene ketal in five simple steps to iodoacetamide ketone 10, which was cyclized in good yield to the key bridged keto lactam 11 containing the A/B 2-azabicyclo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527037/ https://ncbi.nlm.nih.gov/pubmed/16496992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo052466b |
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