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The ionic environment determines ribozyme cleavage rate by modulation of nucleobase pK (a)
Several small ribozymes employ general acid–base catalysis as a mechanism to enhance site-specific RNA cleavage, even though the functional groups on the ribonucleoside building blocks of RNA have pK (a) values far removed from physiological pH. The rate of the cleavage reaction is strongly affected...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525962/ https://ncbi.nlm.nih.gov/pubmed/18697921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1102308 |
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