Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways

The yeast URA2 gene, encoding the rate-limiting enzyme of UTP biosynthesis, is transcriptionally activated by UTP shortage. In contrast to other genes of the UTP pathway, this activation is not governed by the Ppr1 activator. Moreover, it is not due to an increased recruitment of RNA polymerase II a...

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Main Authors: Kwapisz, Marta, Wery, Maxime, Després, Daphné, Ghavi-Helm, Yad, Soutourina, Julie, Thuriaux, Pierre, Lacroute, François
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525842/
https://ncbi.nlm.nih.gov/pubmed/18716630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.165
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