Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

Human immunodeficiency virus (HIV) disease leads to impaired B cell and antibody responses through mechanisms that remain poorly defined. A unique memory B cell subpopulation (CD20(hi)/CD27(lo)/CD21(lo)) in human tonsillar tissues was recently defined by the expression of the inhibitory receptor Fc-...

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Dettagli Bibliografici
Autori principali: Moir, Susan, Ho, Jason, Malaspina, Angela, Wang, Wei, DiPoto, Angela C., O'Shea, Marie A., Roby, Gregg, Kottilil, Shyam, Arthos, James, Proschan, Michael A., Chun, Tae-Wook, Fauci, Anthony S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2008
Soggetti:
Brief Definitive Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525604/
https://ncbi.nlm.nih.gov/pubmed/18625747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072683
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