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Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens
The Sigirr gene (also known as Tir8) encodes for an orphan receptor of the Toll-like receptor (TLR)/interleukin 1 receptor family that inhibits TLR-mediated pathogen recognition in dendritic cells. Here, we show that Sigirr also inhibits the activation of dendritic cells and B cells upon exposure to...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525585/ https://ncbi.nlm.nih.gov/pubmed/18644972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072646 |
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