IL-17 produced by Paneth cells drives TNF-induced shock

Tumor necrosis factor (TNF) has very potent antitumor activity, but it also provokes a systemic inflammatory response syndrome that leads to shock, organ failure, and death. Here, we demonstrate that interleukin (IL)-17, a proinflammatory cytokine known to be produced mainly by activated T cells, ha...

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Autors principals: Takahashi, Nozomi, Vanlaere, Ineke, de Rycke, Riet, Cauwels, Anje, Joosten, Leo A.B, Lubberts, Erik, van den Berg, Wim B., Libert, Claude
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
Matèries:
Brief Definitive Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525583/
https://ncbi.nlm.nih.gov/pubmed/18663129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080588
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