Human interleukin 17–producing cells originate from a CD161(+)CD4(+) T cell precursor

We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17–producing cells are contained in the CD161(+) fraction of CD4(+) T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural...

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Main Authors: Cosmi, Lorenzo, De Palma, Raffaele, Santarlasci, Veronica, Maggi, Laura, Capone, Manuela, Frosali, Francesca, Rodolico, Gabriella, Querci, Valentina, Abbate, Gianfranco, Angeli, Roberta, Berrino, Liberato, Fambrini, Massimiliano, Caproni, Marzia, Tonelli, Francesco, Lazzeri, Elena, Parronchi, Paola, Liotta, Francesco, Maggi, Enrico, Romagnani, Sergio, Annunziato, Francesco
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2008
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525581/
https://ncbi.nlm.nih.gov/pubmed/18663128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080397
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