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Reconstitution of Modular PDK1 Functions on Trans-Splicing of the Regulatory PH and Catalytic Kinase Domains
The serine-threonine protein kinases PDK1 and PKB each contain a pleckstrin homology (PH) domain that binds the membrane-bound phosphatidylinositol 3,4,5-triphosphate [PI(3,4,5)P(3)] second messenger and is required for PDK1-catalyzed phosphorylation and activation of PKB. While X-ray structures hav...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525508/ https://ncbi.nlm.nih.gov/pubmed/17500509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc070055r |
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